Table 4.
PSA and hormone profile values at pre-specified time points.
| Pretreatment | 4th week | 25th week | 1 monthafter enza | 3 months after enza | 6 months after enza | P-value | |
|---|---|---|---|---|---|---|---|
| PSA (ng/ml) | (n = 56) | (n = 52) | (n = 50) | (n = 51) | (n = 51) | (n = 51) | Pre vs 4th w: p <0.0001 Pre vs 25th w p <0.0001 |
| Mean ± SD | 7.61 ± 2.82 | 2.98 ± 2.37 | 0.04 ± 0.04 | 0.09 ± 0.12 | 0.28 ± 0.29 | 0.29 ± 0.28 | Pre vs 1 m p <0.0001 |
| (range) | (3.53–16.77) | (0.22–11.50) | (0.00–0.16) | (0.00–0.52) | (0.01–1.21) | (0.01–1.11) | Pre vs 3 m p <0.0001 |
| 95% CI | 6.87–8.35 | 2.33–3.62 | 0.03–0.05 | 0.06–0.12 | 0.20–0.36 | 0.21–0.36 | Pre vs 6 m p <0.0001 |
| Testosterone (ng/ml) | (n = 53) | (n = 48) | (n = 48) | (n = 48) | (n = 49) | (n = 46) | Pre vs 4th w: p <0.0001 Pre vs 25th w p <0.0001 |
| Mean ± SD | 5.41 ± 2.74 | 9.83 ± 4.18 | 9.16 ± 4.52 | 8.04 ± 4.25 | 7.49 ± 10.55 | 4.82 ± 3.633 | Pre vs 1 m p <0.0001 |
| (range) | (2.20–18.19) | (3.11–19.00) | (1.70–21.10) | (1.40–24.27) | (1.70–69.35) | (1.30–25.91) | Pre vs 3 m p = 0.154 |
| 95% CI | 4.68–6.15 | 8.65–11.02 | 7.88–10.44 | 6.84–9.25 | 4.53–10.44 | 3.77–5.87 | Pre vs 6 m p = 0.285 |
| Estradiol (pg/ml) | (n = 48) | (n = 44) | (n = 45) | (n = 44) | (n = 41) | (n = 39) | Pre vs 4th w: p <0.0001 Pre vs 25th w p <0.0001 |
| Mean ± SD | 26.52 ± 9.59 | 44.40 ± 17.56 | 41.72 ± 19.93 | 40.37 ± 16.78 | 30.05 ± 10.61 | 30.59 ± 10.62 | Pre vs 1 m p <0.0001 |
| (range) | (10.00–47.70) | (14.00–87.00) | (0.00–85.00) | (0.00–72.00) | (12.00–51.00) | (10.00–54.00) | Pre vs 3 m p = 0.015 |
| 95% CI | 23.80–29.23 | 39.21–49.59 | 35.90–47.54 | 35.41–45.33 | 26.80–33.30 | 27.25–33.92 | Pre vs 6 m p = 0.057 |
| LH (mUl/ml) | (n = 51) | (n = 49) | (n = 49) | (n = 46) | (n = 44) | (n = 45) | Pre vs 4th w: p <0.0001 Pre vs 25th w p <0.0001 |
| Mean ± SD | 6.99 ± 4.98 | 13.19 ± 6.69 | 19.24 ± 8.46 | 17.49 ± 8.47 | 12.56 ± 6.67 | 11.12 ± 5.43 | Pre vs 1 m p <0.0001 |
| (range) | (2.08–30.72) | (4.83–35.95) | (7.34–39.20) | (7.24–39.40) | (5.50–32.60) | (4.68–30.24) | Pre vs 3m p <0.0001 |
| 95% CI | 5.62–8.36 | 11.32–15.07 | 16.87–21.61 | 15.04–19.94 | 10.59–14.53 | 9.54–12.71 | Pre vs 6m p <0.0001 |
| FSH (mUl/ml) | (n = 48) | (n = 45) | (n = 44) | (n = 41) | (n = 40) | (n = 40) | Pre vs 4th w: p = 0.055 Pre vs 25th w p <0.0001 |
| Mean ± SD | 13.73 ± 18.77 | 15.11 ± 18.68 | 28.86 ± 15.51 | 27.14 ± 13.95 | 27.49 ± 12.08 | 27.43 ± 12.70 | Pre vs 1 m p <0.0001 |
| (range) | (2.20–126.24) | (2.30–116.44) | (9.20–81.17 | (11.40–88.66) | (10.68–79.05) | (9.51–84.71) | Pre vs 3m p <0.0001 |
| 95% CI | 8.42–19.04 | 9.66–20.57 | 24.27–33.44 | 22.87–31.41 | 23.74–31.23 | 23.49–31.36 | Pre vs 6m p <0.0001 |