Skip to main content
. 2022 Jul 14;13:922318. doi: 10.3389/fimmu.2022.922318

Figure 5.

Figure 5

GC shutdown due to limited B cell division capacity (Mechanism 7). (A, B) K vs number of DZ-LZ cycles according to Equation 11 (A) and GC dynamics (B) for assumptions A1-A4. Colors represent different values of K K as shown above the panels and black curves represent the control simulation. K K controls the increase in K with increasing number of DZ-LZ cycles. The value of K determines the dependence of the number of divisions on the amount of antigen captured in assumptions A1/A2 or Tfh signals acquired by B cells in A3/A4 (see Methods). Solid lines and shaded regions represent mean and standard deviation of 50 simulations, respectively. (C) Average antigen uptake per B cell, Tfh signals acquired per B cell, average number of divisions per recycling GC B cell and fraction of Tfh selected LZ B cells (with K K = 5). Readouts were normalized with that of the control simulation. Colors represent the assumptions A1-A4. Error bars represent standard deviation of 50 simulations. GC, Germinal center; Tfh, T follicular helper cell; Ag, Antigen; DZ, Dark zone; LZ, Light zone.