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. 2022 Jul 14;12:928605. doi: 10.3389/fonc.2022.928605

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Copyright © 2022 He, Zhang, Pang, Yin, Mu, Wang, Ge, Ma, Yang, Zheng, Dong, Zhang, Chang, Li, Tang, Bao, Wu, Wang, Shao, Yu and Yuan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of genetic variations and the associations of dCRT survival outcomes with the KEAP1-NRF2 pathway. (A) The distribution of various genetic variations in each patient was shown. Clinical characteristics of each patient were shown at the bottom. ADC, adenocarcinoma; SCC, squamous cell carcinoma. (B) Lollipop plot showing the distribution of KEAP1 mutations in the study cohort. (C, D) Kaplan-Meier estimates of (C) PFS and (D) OS in the full analysis set comparing patients with and without KEAP1-NRF2 pathway gene mutations. HR denotes hazard ratio; CI denotes confidence interval. Tick marks indicate censored data.