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Genetic variants associated with incidence of high-grade radiation toxicity. (A–C) The proportions of patients carrying the indicated polymorphisms that developed high-grade (A) radiation-induced pneumonitis, (B) radiation-induced esophagitis, and (C) overall pneumonitis and esophagitis. (D) The proportions of patients carrying ZNF217 amplification or POLD1 mutations that developed high-grade radiation-induced toxicity events as indicated.
