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Recognition of H3Q5ser by WDR5. (A) Left: overall structure of WDR522–334 in complex with H3Q5ser1–14 peptide (red). Right: enlarged view showing residues of WDR522–334 (yellow) interacting with Q5ser (red). Hydrogen bonds are shown with blue dashed lines. (B) Lysine at fourth position is protruding away from the WDR5, resulting in no effect of trimethylation of K4 on the Q5ser–WDR5 interaction (PDB ID: 7CFQ).
