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. 2022 Jul 14;9:952114. doi: 10.3389/fcvm.2022.952114

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Copyright © 2022 Li, Song, Tien, Qi, Graves, Nasiotis, Burris, Zhao, Sun and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The rhythmic expression of REV-ERB in the major cell types of the heart. (A–C) Relative mRNA expression levels of Nr1d1 and Nr1d2 in major cell types in the heart (CM-cardiomyocytes, CF-cardiac fibroblasts and Endo-endothelial cells) isolated from mouse hearts at 6 weeks after TAC or sham surgery at ZT6 or ZT18. ^#p < 0.05, *P < 0.05, **p < 0.01, ***P < 0.001 by two-way ANOVA. Tukey’s test was used for multiple comparison corrections. n = 3. (D) Diagram of the SR9009 treatment schemes. Mice receive daily SR9009 injection post-TAC at ZT06 or ZT18 for 6 weeks. ****P < 0.0001.