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. 2022 Jul 22;11(15):2262. doi: 10.3390/cells11152262

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The role of autophagy in the regulation of embryonic development. (a) Autophagy as a regulator of embryonic development and neural development. Mouse models suggest that autophagy is essential for development. (b) Autophagy interacts with developmental signaling pathways, among them Notch, Wnt, Sonic Hedgehog, FGF, and TGFβ. Impairments in the crosstalk between these pathways and autophagy could likely be the cause of the defects in the generation of embryonic structures. See the text above for more details. “Created with BioRender.com (accessed on 1 May 2022)”.