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. 2022 Jul 14;12:901951. doi: 10.3389/fonc.2022.901951

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Copyright © 2022 El Khayari, Bouchmaa, Taib, Wei, Zeng and El Fatimy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of adaptive lipid metabolism in glioblastoma: role of the highly expressed ACBP, DGAT1, GPx4, and lipid droplets in lipid oxidation and ferroptosis induction. FAs, Fatty acids; FAO, Fatty acid oxidation; PUFA, Polyunsaturated fatty acids; DGAT1, diacylglycerol-acyltransferase 1; ACSL4, acyl-CoA synthetase long-chain family member 4; GPX4, glutathione peroxidase; GR, glutathione reductase; LD, lipid Droplet; LPO, lipid peroxides; ACBP, Acyl-CoA-binding protein; LDLR, low-density lipoprotein receptor; ER, Endoplasmic Reticulum.