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. 2022 Jul 22;10(8):1776. doi: 10.3390/biomedicines10081776

Figure 6.

Figure 6

GW treatment attenuated 6-OHDA-induced deficits in the elevated plus-maze (EPM) test, novelty-suppressed feeding (NSF) test, marble burying test (MBT), and forced swim test (FST). (A,B) In the EPM test, neither 6-OHDA or drug treatments had a significant effect on open arm time ((A) p > 0.05) or the number of open arm entries ((B) p > 0.05). (C,D) In the NSF test, 6-OHDA injection increased feeding latency in a novel environment ((C) *** p < 0.001; n = 8–9 mice) compared to the controls. GW treatment prevented the increase in latency to feed in a novel environment (* p = 0.015; n = 8–8 mice), but co-treatment with AM blocked the effect of GW (* p = 0.049; n = 8–10 mice). However, when returned to the home cage (D) 6-OHDA injection and GW treatment had no effect (p > 0.05). (E) In the MBT, 6-OHDA injection increased the number of marbles buried (*** p < 0.001; n = 8–9 mice). Treatment with GW blocked the increase in marble burying (* p = 0.002; n = 8–8 mice), and co-treatment with AM prevented the effect of GW (* p = 0.037; n = 8–10 mice). (F) 6-OHDA injection increased immobility time in the FST (*** p < 0.001; n = 8–9 mice), which was ameliorated by treatment with GW (** p = 0.004; n = 8–8 mice). The effect of GW was blocked by AM co-treatment (* p = 0.035; n = 8–10 mice).