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. 2022 Jul 22;14(8):1527. doi: 10.3390/pharmaceutics14081527

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of both AIT treatment strategies on the humoral immune response in a murine model of allergic asthma. Measurement of total IgE (a), OVA-sIgE (b), total IgG1 (c), and OVA-sIgG1 (d) in serum samples at the endpoint of the experiment (n = 10). Gaussian and non-Gaussian distributed results were analyzed by unpaired t-test or Mann–Whitney test, respectively. p-values of ≤0.05, ≤0.01, ≤0.001, and ≤0.0001 are shown as *, **, ***, and ****, respectively. p-values of AIT groups compared to the respective non-allergic groups are shown as +++ and ++++, respectively.