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. 2022 Jul 14;9:892377. doi: 10.3389/fvets.2022.892377

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Copyright © 2022 Tan, Li, Ueda, Stern, Hussain, Haginoya, Sharpe, Gunther-Harrington, Epstein and Nguyen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cats with naturally occurring wildfire injuries (WF) had elevated circulating platelet-derived microvesicles (PDMV). PDMV was measured in platelet poor plasma in 29 WF cats and 8 healthy control cats by flow cytometry. (A–C) Representative scatter dot plot diagrams of flow cytometric analysis of PDMV identified based on size, side scatter properties and co-expression of integrin β3 (CD61) and phosphatidylserine (PS) – P2. (A) Representative scatter plot generated from a cat with wildfire-related injuries, (B) from a control cat without hypertrophic cardiomyopathy and (C) positive control generated by activating platelets with 2 mM calcium and the calcium ionophore, A23187 (2.5 μM), which showed a significant increase in PDMV compared to resting sample. (D,E) WF cats not only had increased number of PDMV but a greater percentage of them had externalized PS compared to healthy controls. *p < 0.05.