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. 2022 Jul 14;13:935257. doi: 10.3389/fgene.2022.935257

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Copyright © 2022 Sampson, Wolska, Meeusen, Donato, Jaffe and Remaley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VLDL-C/TG ratio comparison in HLP3 and non-HLP3 patients. VLDL-C was calculated by the Sampson VLDL-C/TG (S-VLDL-C/T) (A) and enhanced Sampson VLDL-C/TG (eS-VLDL-C/T) (B) equations in the validation dataset (N = 12,405) from the results of a standard lipid panel. HLP3 was defined as VLDL-C/TG > 0.3 mg/dl and TG between 150–1,000 mg/dl using the BQ results. The ROC curves are plotted for the Sampson VLDL-C/TG (S-VLDL-C/T) (C) and enhanced Sampson VLDL-C/TG (eS-VLDL-C/T) (D) equations. The optimal cut-point (blue circle) and its corresponding sensitivity and specificity are indicated for each equation.