Table 4.
Odds ratios (ORs) for the optimal cut-off values, determined by Youden’s J statistics on the respective ROC curves.
| Biomarker | OR [95% CI] | p-Value |
|---|---|---|
| C1M | 14.08 [2.35–59.09] | 0.002 |
| C3M | 15.60 [2.79–80.36] | 0.002 |
| PRO-C3 | 3.56 [0.61–19.27] | 0.229 |
| C3M/PRO-C3 a | 13.00 [2.12–54.97] | 0.004 |
| C4M | 8.93 [1.62–42.45] | 0.012 |
| C4G | 1.09 [0.2677–4.960] | >0.999 |
| PRO-C4 | 9.60 [1.67–39.52] | 0.006 |
| C4M/C4G a | 11.25 [2.08–58.41] | 0.008 |
| PRO-C4/C4M a | 5.33 [1.19–21.94] | 0.062 |
| PRO-C4/C4G a | 2.62 [0.27–39.81] | 0.579 |
| C6Ma3 | 15.75 [2.01–182.70] | 0.007 |
| CPa9-HNE | 19.43 [2.36–255.20] | 0.004 |
| CPa9-HNE/C4G a | 11.33 [1.25–136.10] | 0.030 |
Abbreviations: OR, odds ratios; CI, confidence interval. Cut-off values based on specificity and sensitivity are shown in table. a Biomarker ratios with no concentration unit.