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. 2022 Jul 22;23(15):8061. doi: 10.3390/ijms23158061

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Protein translation contributes to lipotoxicity-induced increase in hERG1a/1b. (A) Experimental protocol: macroscopic hERG1a/1b currents were measured in HEK293 cells under control conditions (B) and after pre-exposure to lipotoxicity (C) for 2 h, using the illustrated voltage protocol. (D–I) Exemplar traces, pooled I_peak–V curves, and averaged current amplitude measured at +10 mV under the effects of DRB (, and blue line) and Cyc (, and orange line). The I_peak–V curves for hERG1a/1b currents measured in control cells (black line in (E,H)) and in cells pre-treated with lipotoxicity (red line in (E,H)) are shown for comparison. (* statistical significance at p < 0.05).

Inline graphic — Protein translation contributes to lipotoxicity-induced increase in hERG1a/1b. (A) Experimental protocol: macroscopic hERG1a/1b currents were measured in HEK293 cells under control conditions (B) and after pre-exposure to lipotoxicity (C) for 2 h, using the illustrated voltage protocol. (D–I) Exemplar traces, pooled I_peak–V curves, and averaged current amplitude measured at +10 mV under the effects of DRB (, and blue line) and Cyc (, and orange line). The I_peak–V curves for hERG1a/1b currents measured in control cells (black line in (E,H)) and in cells pre-treated with lipotoxicity (red line in (E,H)) are shown for comparison. (* statistical significance at p < 0.05).