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. 2022 Jul 22;23(15):8061. doi: 10.3390/ijms23158061

Figure 7.

Figure 7

High-fat-diet feeding upregulated IKr and shortened action potential duration in adult guinea pig atria. (A) Experimental protocol: IKr tail current density and APs were measured in guinea pigs fed an LFD or HFD for 50 days. (B–E) Exemplar IKr tail current traces, population Ipeak–V, and averaged current amplitude at +10 mV measured in freshly isolated atrial myocytes. Pooled I–V curves (in D) represent IKr tail current density measured in LFD-fed control myocytes (black symbol and line) and HFD-challenged myocytes (red symbol and line). (F–I) Current-clamp analysis of AP morphology in atrial myocytes from LFD- and HFD-fed guinea pigs. Electrophysiology data were generated from cardiomyocytes from three guinea pigs per diet group. (* statistical significance at p < 0.05).