Table 4.

Top Candidate Genes.

Gene					miRNA Variant				3′ UTR Variant
Gene	Max Brain Expression	Other NDD	pLI	Previous Studies	miRNA	Inheritance	Family	Phenotype	chr	pos	rsID	AF_gnomAD	Inheritance	Family	Phenotype
ONECUT2	66	NA	0.91	[33]	hsa-miR-6780a-3p	dominant	FAM5	RI	chr18	55155836	rs147208471	7.27 × 10−4	dominant	FAM56	SRS
OSBP	61.03	NA	1.00	[34]	hsa-miR-6780a-3p	dominant	FAM5	RI	chr11	59343007	rs149325846	3.61 × 10−3	dominant	FAM14; FAM66	RI
SCP2	65.43	ASD_Low	0.00	[35]	hsa-miR-6780a-3p	dominant	FAM5	RI	chr1	53516762	rs182947399	1.33 × 10−3	dominant	FAM2	ADHD
TUB	187	NA	0.00	[36,37]	hsa-miR-6780a-3p	dominant	FAM5	RI	chr11	8123523	rs1379616749	3.12 × 10−4	dominant	FAM70	RI
RBM24	49.40	NA	0.09	[38]					chr6	17292448	rs914886490	2.60 × 10−4	de novo	FAM5; FAM59	ADHD,LI
UGCG	86	NA	0.94	[31,32]					chr9	114695431	rs201977317	4.54 × 10−3	dominant	FAM5; FAM36; FAM37	RI,SRS

Other NDD: genes implicated in NDDs from previous studies (Table S2). pLI: the probability the gene is loss-of-function intolerant. AF_gnomAD: maximum variant AF in the three gnomAD databases. Other headers are the same as in Table 2.