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. 2022 Jul 14;13:885685. doi: 10.3389/fimmu.2022.885685

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Copyright © 2022 Zou, Bai, Kong, Xu, Ding, Zhang, Dong, Ling and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic diagram illustrating the possible mechanism of KCR in peripheral nerve injury-induced neuropathic pain. The left panel represents establishing the facial and somatic neuropathic pain animal models. The middle panel illustrates that peripheral nerve injury induces macrophage activation in TG or DRG. The right panel schematically indicates histone lysine crotonylation increased in macrophages after injury, resulting in the transcriptional enhancement of Tnfα, Il1β, Ccl2 and Cxcl10. These processes ultimately cause neuropathic pain.