TABLE 3.
Estimation of the bioequivalence for ivermectin (ivermectin/albendazole FDC vs. ivermectin) and albendazole (ivermectin/albendazole FDC vs. albendazole).
| Parameter | FDC (Geom.mean) | Reference (Geom.mean) | T/R ratio | 90% confidence interval | Outcome | |
|---|---|---|---|---|---|---|
| Ivermectin | C max | 83.5 | 72.31 | 118.48 | 110.68–120.49 | Bioequivalent |
| AUC 0-72 | 1,000.09 | 870.12 | 114.94 | 110.46–119.60 | Bioequivalent | |
| Albendazole | C max | 15.74 | 25.76 | 61.11 | 53.10–70.34 | No bioequivalent |
| AUC 0-t | 74.42 | 108.80 | 68.40 | 61.13–76.54 | No bioequivalent |
Cmax, Maximum plasma concentration; AUC0-72, Area under the curve from time zero to 72 h; AUC0-t, Aurea under the curve from time zero to 48 h post-administration.