Table 5.
Comparison of subgroups of COVID-19 patients depending on the severity of the disease.
| Laboratory Parameter | Moderately Severe (n = 85) 1 |
Severe (n = 34) 1 |
Normal Range | p-Value (Mann–Whitney) 1 |
|---|---|---|---|---|
| Creatinine, μmol/L | 124 [83; 151] | 114 [101; 143] | 63–110 (male) 50–98 (female) |
0.68 |
| Total calcium, mmol/L | 2.20 [2.14; 2.31] | 2.15 [2.04; 2.23] | 2.15–2.55 | 0.04 |
| Albumin, g/L | 40 [36; 42] | 39 [36; 42] | 35–50 | 0.28 |
| Albumin-adjusted calcium, mmol/L | 2.24 [2.17; 2.29] | 2.21 [2.15; 2.26] | 2.15–2.55 | 0.16 |
| Phosphorus, mmol/L | 1.07 [0.94; 1.19] | 1.09 [0.90; 1.25] | 0.74–1.52 | 0.63 |
| Free 25OH-D, pg/mL | <LoB 2.7 [2.1; 3.3] |
<LoB 2.2 [1.8; 4.7] |
2.4–35 2 | 0.80 0.90 |
| DBP, mg/L | 450 [391; 509] 342 [290; 434] |
442 [355; 531] 353 [267; 473] |
200–550 2 | 0.91 0.75 |
| 25OH-D3, ng/mL | 10.9 [6.4; 16] 9.8 [5.7; 14.1] |
8.8 [5.7; 15.5] 9.1 [3.3; 12.4] |
>30 3 | 0.29 0.48 |
| 3-epi-25OH-D3, ng/mL | 0.6 [0.4; 1.1] 0.6 [0.4; 1.0] |
0.7 [0.3; 0.8] 0.6 [0.2; 0.8] |
not available | 0.44 0.59 |
| 24,25(OH)2D3, ng/mL | 0.5 [0.1; 0.9] 0.4 [0.1; 0.9] |
0.3 [0.2; 0.7] 0.3 [0.1; 0.7] |
0.5–5.6 4 | 0.26 0.33 |
| 1,25(OH)2D3, pg/mL | 64 [46; 83] 34 [24; 43] |
54 [41; 79] 32 [15; 50] |
25–66 4 | 0.18 0.41 |
1 The first value corresponds to the baseline examination; the second value corresponds to the follow-up examination. 2 Ranges are specified according to kit manufacturers’ recommendations. 3 Range is given for a total of 25OH-D according to the clinical guidelines [40,41]; the 25OH-D2 fraction is negligible for the purposes of this study. 4 Ranges are given according to the literature data [42,43].