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. Author manuscript; available in PMC: 2022 Jul 28.
Published in final edited form as: Transl Res. 2020 Nov 20;230:139–150. doi: 10.1016/j.trsl.2020.11.010

Figure 1. Imprinting control region (ICR) on the IGF2-H19 locus determines the expression lncRNA H19.

Figure 1.

The relative location of DMRs (differentially methylated regions), IGF2 (insulin-like growth factor 2), ICR, H19, and enhancer were presented in Fig. 1A. On the paternal allele (Fig. 1B left), ICR is hypermethylated and prevents the expression of H19. In contrast, on maternal allele (Fig. 1B right), ICR is unmethylated and CCCTC binding factor (CTCF) is recruited. The enhancer binds the H19 promoter and activates its expression.