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. 2022 Jul 12;7(29):25346–25352. doi: 10.1021/acsomega.2c02287

Table 2. Inhibitors with No Preincubation in Cathepsin B Assays at pH 4.6 with the Z-EK-AMC Substratea.

inhibitor (5 μM) % control cathepsin B activity
none 100
GER-12 28
GER-24 80
GER-163 103
GER-165 112
GER-169 99
GER-170 101
ST024730 110
a

The indicated NP molecules were assessed at 5 μM, with no preincubation of inhibitor and cathepsin B enzyme, in assays using the substrate Z-EK-AMC at pH 4.6.