Table 2. Inhibitors with No Preincubation in Cathepsin B Assays at pH 4.6 with the Z-EK-AMC Substratea.
| inhibitor (5 μM) | % control cathepsin B activity |
|---|---|
| none | 100 |
| GER-12 | 28 |
| GER-24 | 80 |
| GER-163 | 103 |
| GER-165 | 112 |
| GER-169 | 99 |
| GER-170 | 101 |
| ST024730 | 110 |
The indicated NP molecules were assessed at 5 μM, with no preincubation of inhibitor and cathepsin B enzyme, in assays using the substrate Z-EK-AMC at pH 4.6.