Table 3. Assessment of Mutagenic Potential for PPADT and the Monomer Using Ames MPF Assaya.
results |
|||||
---|---|---|---|---|---|
strain
TA98 |
strain TA100 |
||||
compound | highest conc. (μg/mL) | –S9 | +S9 | –S9 | +S9 |
PPADT | 4.369 | √ | √ | ||
monomer (1,4-benzenemethanethiol) | 15.36 | √ | √ | √ | √ |
The strains used were TA98 (frameshift mutation) and TA100 (base-pair substitution). Metabolic activation (+S9) was only applied when testing the monomer. (√) no observed revertants above threshold.