Table 3. Adjusted Association Between Early LVEF Improvement and 5-Year Clinical Outcomes After Transcatheter Aortic Valve Replacementa.
| Outcome | LVEF improvement (per 5% increase) | Increase in LVEF ≥10% points | ||
|---|---|---|---|---|
| aHR (95% CI) | P value | aHR (95% CI) | P value | |
| All-cause death | 0.94 (0.88-1.00) | .04 | 0.79 (0.62-1.02) | .06 |
| Cardiac death | 0.90 (0.82-0.98) | .02 | 0.75 (0.53-1.05) | .09 |
| Noncardiac death | 0.97 (0.87-1.07) | .51 | 0.82 (0.54-1.22) | .32 |
| Rehospitalization | 0.98 (0.92-1.06) | .64 | 0.93 (0.70-1.22) | .59 |
| Death or rehospitalization | 0.97 (0.92-1.03) | .31 | 0.88 (0.70-1.09) | .24 |
| Cardiac death or rehospitalization | 0.99 (0.93-1.05) | .66 | 0.97 (0.76-1.24) | .82 |
Abbreviations: aHR, adjusted hazard ratio; LVEF, left ventricular ejection fraction.
a
Multivariable models adjusted for the following covariates: sex, body mass index, Society of Thoracic Surgeons score, diabetes, prior myocardial infarction, cancer, and baseline LVEF.