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. 2022 Jul 24;10(8):1782. doi: 10.3390/biomedicines10081782

Figure 2.

Figure 2

MiWAS result and epistasis screening. (A) Mitochondrial solar plot of MiWAS result. Nine MT-SNPs with a nominal p-value < 0.05 were considered statistically significant associates with AD risk (Table S1). Six of them are located in the control region of the mitochondria. (B) Epistasis screening of nine MT-SNPs significantly related to AD risk. A total of 54,942 (AD/no dementia) and 38,643 (AD/MCI) MT-nuclear SNP interactions met the criteria of a cell size either more than 3 or equal to 0 and a nominal p threshold of 0.05. Among them, there were 14,340 MT-nuclear SNP interactions replicated in the 2 contrast groups (Table S4).