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. 2022 Jul 24;10(8):1782. doi: 10.3390/biomedicines10081782

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Construction and evaluation of AD predictive models based on AlzData. (A) Performance of predictive models based on AlzData. Due to the lack of expression values of approximately 2/3 hub genes, the FC region had the lowest AUC (0.610). For the other three regions, HP, EC, and TC, AUC values reached 0.757, 0.788, and 0.808, respectively. Kaplan–Meier survival curves showed that individuals in the high-risk group exhibited a significantly earlier age of AD onset in EC (B), HP (C), TC (D), and FC (E) (Log-rank test, p < 0.0001 (excluding AlzData_TC p = 0.0006)). Abbreviations: EC, Entorhinal Cortex; HP, Hippocampus; TC, Temporal Cortex; FC, Frontal Cortex.

Construction and evaluation of AD predictive models based on AlzData. (A) Performance of predictive models based on AlzData. Due to the lack of expression values of approximately 2/3 hub genes, the FC region had the lowest AUC (0.610). For the other three regions, HP, EC, and TC, AUC values reached 0.757, 0.788, and 0.808, respectively. Kaplan–Meier survival curves showed that individuals in the high-risk group exhibited a significantly earlier age of AD onset in EC (B), HP (C), TC (D), and FC (E) (Log-rank test, p < 0.0001 (excluding AlzData_TC p = 0.0006)). Abbreviations: EC, Entorhinal Cortex; HP, Hippocampus; TC, Temporal Cortex; FC, Frontal Cortex.