Table 1.

Aberrantly expressed miRNAs associated with the brain-heart axis and inflammation after SARS-CoV-2 infection.

	miRNA	Type of sample	Regulation	Validated targets in COVID-19	Reference
Brain	miR-24	hBMECs	↑	NRP1	[17]
Cardiac	miR-21-5p	Serum, RBC-depleted whole blood,	↑	MYC	[18], [19]
	miR-200c	NRCMs, NRCFs, HCFs, HUVECS, cord blood derived hiPSC-CMs	↓	ACE	[20]
	miR-133a, miR-122	Plasma	↑↓	–	[21]
	miR-208a	Serum	↑	–	[19]
	miR-499		↑	FoxO1
Inflammation	miR-155		↑	–
	miR-16-2-3p	Blood	↑	–	[22], [23]
	miR-6501-5p		↑
	miR-618		↑	TLR-4, HAT1, TGF-β2
	miR-183-5p		↓	PTEN
	miR-627-5p		↓	–
	miR-144-3p		↓	FoxO1
	miR-423-5p	Plasma	↑	–	[24]
	miR-23a-3p		↓	–
	miR-195-5p		↑	–
	miR-1207-5p	Lung tissue	↑	CSF1	[25]
	miR-146a-5p	Serum, RBC-depleted whole blood,	↓	IL-6, STAT1	[18], [26]
	miR-429	RBC-depleted whole blood	↓	–	[18]
	miR-142-3p		↑	IL6ST
	miR-15b-5p		↑	IFNG, CD69
	miR-26a-5p	Post mortem lung tissue	↓	–	[27]
	miR-29b-3p
	miR-34a-5p

hBMECs indicates human brain microvascular endothelial cells, HCFs – human cardiac fibroblasts, hiPSC-CMs - human induced pluripotent stem cell-derived cardiomyocytes, HUVECs – human umbilical vein endothelial cells, NRCFs - neonatal rat cardiac fibroblasts, NRCMs - neonatal rat cardiomyocytes, RBC – red blood cells.