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. 2022 Jul 14;13:866705. doi: 10.3389/fmicb.2022.866705

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Copyright © 2022 Troyano-Hernáez, Reinosa and Holguín.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amino acid conservation rate along RT in HIV-1 and group M consensus. Aa, amino acid; M, group M consensus. RT, reverse transcriptase (440 aa). Dots in group M represent the same aa as in HIV-1 consensus for that position. HXB2 reference sequence is described below the groups for further guidance. Colors represent the conservation rate. Residues of the catalytic triad (Asp110, Asp185, and Asp186) are highlighted in red font. Blue crosses and blue diamonds indicate positions where DRM to NRTI and to NNRTI, respectively, are located according to Stanford v9.0 (Release Notes - HIV Drug Resistance Database, 2020). Aa code according to Figure 3.