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. 2022 Jul 14;13:866705. doi: 10.3389/fmicb.2022.866705

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Copyright © 2022 Troyano-Hernáez, Reinosa and Holguín.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amino acid conservation rate along IN in HIV-1 and group M consensus. Aa, amino acid; M, group M consensus. IN, integrase (288 aa). Dots in group M represent the same aa as in HIV-1 consensus for that position. HXB2 reference sequence is described below the groups for further guidance. Colors represent the conservation rate. Residues of the zinc-binding site (His12, His16, Cys40, and Cys43) and the D–D–E motif of the catalytic domain (Asp64, Asp116, and Glu152) are highlighted in red font. Green circles indicate positions where major INSTIs DRM are located according to Stanford v9.0 (Release Notes - HIV Drug Resistance Database, 2020). Aa code according to Figure 3.