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. 2022 Jul 14;13:866705. doi: 10.3389/fmicb.2022.866705

TABLE 2.

Single V-markers and R-markers in protease found across HIV-1 variants with >5 LANL sequences.

HIV-1 variant Countries V-markers and R-markers (bold red)
Group O
(24)		 Belgium (2), Cameroon (12), Senegal (3), Spain (3), United Kingdom (2), United States (2)
 graphic file with name fmicb-13-866705-i000.jpg
Subtype J
(20)		 Republic of Angola (2), The Democratic Republic of the Congo (2), Central African Republic (3), Congo (1), Cameroon (7), Gabon (1), Spain (1), Senegal (1), Belgium (2)
 Q61E (83%)
CRF08_BC
(431)		 China (430), India (1)
 T12S (87%)
CRF13_cpx
(42)		 Belgium (2), Burkina Faso (1), Cameroon (22), Central African Republic (5), Germany (5), Greenland (1), Poland (1),
Spain (2), The Democratic Republic of the Congo (3)		 graphic file with name fmicb-13-866705-i001.jpg
CRF19_cpx
(178)		 Cuba (172), Spain (4), Tunisia (1), United Kingdom (1) H69Q (75%)
CRF35_A1D
(216)		 Afghanistan (9), China (1), Iran (205), Romania (1) L19Q (76%)
CRF49_cpx
(10)		 Botswana (1), Gambia (3), Germany (4), Nigeria (1), Senegal (1) D60N (90%), Q61D (90%), I66V (80%)
CRF51_01B
(8)		 Singapore (8) L63S (100%)
CRF60_BC
(25)		 Brazil (1), Germany (2), Italy (22) graphic file with name fmicb-13-866705-i002.jpg
CRF63_02A6
(193)		 Kyrgyzstan (2),
Russian Federation (59),
Uzbekistan (132)		 K14R (79%)
CRF89_BF1
(22)		 Argentina (1), Spain (20),
Sweden (1)		 T12E (91%)

In brackets, number of sequences in variant or country and conservation percentage in markers; in bold red font, V-markers that are R-markers. None of the R-markers corresponded to major DRM to PI according to Stanfordv 9.0.