TABLE 3.
Single V-markers and R-markers in reverse transcriptase found across HIV-1 variants with >5 LANL sequences.
| HIV-1 variant | Countries | V-markers and R-markers (bold red) |
| Sub-subtype A6 (85) |
United Kingdom (4), Georgia (1), Italy (1), Russian Federation (79) | K11T (85%), E36D (76%) |
| Subtype C (1607) |
Belgium (4), Brazil (12), Botswana (30), The Democratic Republic of the Congo (4), China (11), Spain (5), United Kingdom (14), Georgia (1), Equatorial Guinea (1), India (65), Kenya (4), Nigeria (1), Nepal (2), Pakistan (1), Rwanda (3), Sweden (9), Senegal (2), Thailand (1), United Republic of Tanzania (37), Uganda (7), United States (5), South Africa (933), Zambia (455) | T39E (78%) |
| Subtype D (238) |
The Democratic Republic of the Congo (2), United Kingdom (2), Kenya (1), South Korea (1), Nigeria (1), United Republic of Tanzania (1), Uganda (229), United States (1) | L282C (91%), P345Q (89%), T377Q (92%), S379C (82%) |
| Sub-subtype F1 (41) |
Germany (1), Spain (22), France (1), United Kingdom (14), Italy (2), United States (1) | D123E (88%), I178L (85%) |
| Subtype G (40) |
The Democratic Republic of the Congo (2), Cameroon (1), Spain (5), United Kingdom (2), Kenya (1), Nigeria (27), Russian Federation (1), South Africa (1) | M357R (93%), Q394R (90%), T400V (83%), F440Y (93%) |
| CRF01_AE (1225) |
Afghanistan (1), China (547), Sweden (3), Thailand (221), United Kingdom (13), United States (3), Viet Nam (437) | V245E (91%) |
| CRF02_AG (110) |
Belgium (1), Benin (2), Cameroon (5), China (2), Spain (5), Gabon (1), United Kingdom (29), Equatorial Guinea (5), Italy (1), South Korea (1), Mexico (1), Nigeria (33), Pakistan (3), Russian Federation (1), Sweden (2), Senegal (9), Togo (7), Thailand (1), United States (1) | S162A (96%) |
| CRF06_cpx (19) |
Burkina Faso (3), China (1), United Kingdom (10), Nigeria (4), Senegal (1) | F346H (84%), R358K (89%) |
| CRF08_BC (129) |
China (129) | E53D (98%), D324E (86%) |
| CRF35_A1D (9) |
Afghanistan (9) | L283I (78%) |
| CRF55_01B (11) |
China (11) |
|
| CRF89_BF (7) |
Spain (7) | Q394L (86%), E399D (100%) |
In brackets, number of sequences in variant or country and conservation percentage in markers; in bold red font, V-markers that are R-markers. None of the R-markers corresponded to major DRM to NRTI or NNRTI according to Stanford v9.0.