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. 2022 Jul 23;10(8):1779. doi: 10.3390/biomedicines10081779

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CCL4 expression in nasal polyps. (A,B) Nasal polyps were obtained from patients with ECRS by excision biopsy under local anesthesia in the outpatient clinic. CCL4 and EpCAM expression in nasal polyps were evaluated pre- and post-treatment with dupilumab. Hematoxylin & Eosin (HE) staining; CCL4 (green), EpCAM (orange), and the nucleus (blue) are shown in upper (pre-treatment) and in lower (post-treatment) panels, respectively (A). Images were obtained using a FV3000 confocal microscope (100× objective). Scale bars in the bottom-left corner of Merge indicate 100 μm. CCL4 intensity is expressed as fold change relative to EpCAM (B). Individual values are shown; ^# p < 0.05 (vs. pre-treatment).