Table 1.

Overview of Piezo1 dysfunctional regulation in cardiac cells (myocytes and fibroblasts) and related cellular/clinical features. * Refers to our hypothesis about Piezo1 beneficial targeting in fibroblasts discussed in the present work.

Cell Type	Expression	Cellular/Clinical Features	References
Cardiomyocytes	knockdown	Reduced sarcoplasmic reticulum Ca2+ content and spontaneous Ca2+ activity Larger heart with dilated left ventricles and fibrosis Attenuated progression of the pathological hypertrophy	[19,20,112]
	overexpression	Arrhythmias Heart failure Hypertrophy Fibrosis	[19,20,112,128]
Cardiac Fibroblasts	knockdown	Inhibited cardiac fibroblasts activation Reduced cytokines release Prevented cell adaptation to substrate feature Prevented cardiac fibrotic invasive character *	[66,127,129] * Our hypothesis discussed in the present work
	overexpression	Atrial fibrillation Increased cytokines release Hypertrophy via IL-6 secretion Increased cell stiffness Favored myofibroblast phenotype Enhanced ECM accumulation Fast recruitment of new myofibroblasts * Increased fibrotic remodeling *	[126,127,129,130,131,132] * Our hypothesis discussed in the present work