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. 2022 Jul 11;12(12):5364–5388. doi: 10.7150/thno.72713

Figure 2.

Figure 2

Autophagosomes acutely accumulate in activated microglia and infiltrating macrophages at 3 days after SCI. Young adult male CX3CR1-GFP mice underwent moderate contusion injury at T10. (A) Immunohistochemistry (IHC) representative images of GFP+(green)/p62+(red)/F4/80+ (blue) cells at 0.3 mm rostral to the epicenter. Insets display the dorsal white matter for quantification. (B-C) Representative images and cell count quantification of p62 (red) and F4/80 (blue) positive cells in the dorsal white matter of CX3CR1-GFP mice. n = 4 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001. Two-tailed unpaired t-test. Scale bar = 500 µm (A) and 50 µm (B).