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. 2022 Jul 11;12(12):5364–5388. doi: 10.7150/thno.72713

Figure 9.

Figure 9

Effects of Trehalose treatment on protein expression level of key inflammatory and autophagic markers. Young adult C57BL/6 mice subjected to moderate contusion injury were given 5% trehalose or sucrose via oral gavage twice per day in addition to treated drinking water. At 3 d after SCI, spinal cord tissue surrounding injury site were dissected for examination of the autophagic and inflammatory markers. Western blot analysis of protein expression for BECLIN-1, LC3-II, p62, and LAMP1 (A), NLRP3 (B), cGAS and STING (C), and IBA-1 (D) and the representative blot images are shown. n = 6 mice/group. * p < 0.05, **p < 0.05, ***p < 0.001 vs. Sham groups; #p < 0.05, ##p < 0.01 vs. SCI/WT; &&& p <0.001 vs. Sham/Suc group. Two-way ANOVA followed by Tukey's multiple comparison.