Table 2.

BMI, HOMA-IR, and AUC_glucose [mean and 95% CI] and estimated mean differences within the per-protocol analysis. Intervention effects are reported as estimated marginal means and estimated mean differences [intervention minus control] based on a mixed-model, repeated-measures analysis of variance adjusted for the treatment group, sex, age, and BMI at baseline

Months after weight loss	Intervention group [kg/m2]	Control group [kg/m2]	Group difference
BMI [kg/m2]
0	31.46 [31.11, 31.81]	31.84 [31.48, 32.20]	-0.39 [-0.84, 0.07]
12	31.71 [31.00, 32.44]**	33.05 [32.29, 33.82]	-1.35 [-2.39, -0.31]
18	33.04 [32.30, 33.79]	33.79 [33.01, 34.56]	-0.74 [-1.80, 0.31]
24	33.47 [32.69, 34.25]	34.09 [33.28, 34.91]	-0.63 [-1.74, 0.48]
36	33.90 [33.15, 34.65]	34.42 [33.60, 35.25]	-0.52 [-1.61, 0.57]
48	34.21 [33.39, 35.03]	34.72 [33.78, 35.66]	-0.51 [-1.74, 0.72]
HOMA-IR
0	1.44 [1.22, 1.67]	1.68 [1.44, 1.91]	-0.24 [-0.53, 0.06]
12	1.60 [1.32, 1.87]*	2.07 [1.77, 2.37]	-0.47 [-0.86, -0.09]
18	2.05 [1.67, 2.42]	2.43 [2.03, 2.84]	-0.39 [-0.93, 0.16]
24	1.98 [1.62, 2.35]	2.36 [1.97, 2.75]	-0.37 [-0.90, 0.15]
36	2.57 [2.01, 3.13]	2.77 [2.11, 3.43]	-0.20 [-1.05, 0.65]
48	2.52 [1.91, 3.14]	3.45 [2.71, 4.19]	-0.93 [-1.88, 0.03]
AUCglucose [mg dl−1 min−1]
0	270 [256, 285]	271 [256, 286]	-0.92 [-20.10, 18.26]
12	275 [257, 292]*	300 [282 –318]	-25.65 [-49.32, -1.99]
18	293 [277, 309]	305 [289, 322]	-12.65 [-34.36, 9.05]
24	297 [277, 318]	325 [304, 347]	-27.77 [-56.09, 0.56]
36	315 [294, 335]	343 [320, 365]	-27.68 [-56.54, 1.18]
48	327 [305, 348]	344 [320, 368]	-17.85 [-48.78, 13.08]

BMI body mass index, HOMA-IR Homeostatic Model Assessment for insulin resistance, glucoseAUC area under the curve of glucose response after oGTT

^*p<0.05

^**p=0.01 vs. control group