Table 2.

Microbiological isolates and treatment regimen.

PT	DTT-NFGN/Organism	MIC90 for CZA (mg/L)	Other Organism	Previous/Empirical Treatment Regimen	CZA Regimen	Days of Therapy
PT1	S. maltophila	2	K. pneumoniae ESBL	FDC then MEM	CZA EI 5 g every 12 h + MEM EI1 g every 8 h	27
PT2	B. cepacia	4			CZA EI 5 g every 12 h + FOF 24 g CI	12
PT3	P. aeruginosa	2		MEM	CZA EI 1.25 g every 8 h + AMK inhaled	9
PT4	P. aeruginosa	2	S. marcescens	FEP	CZA EI 5 g every 12 h + FOF 24 g CI	6
PT5	P. aeruginosa	8	K. pneumoniae	CAZ then TZP then MEM	CZA II over 2 h of 2.5 g + AMK inhaled	18
PT6	P. aeruginosa	4	S. marcescens Colistin-R	MEM	CZA EI 1.25 g every 8 h + FOF 2 g every 48 h, after a dialytic session	18
PT7	P. aeruginosa	16		COL + AMK inhaled	CZA EI 5 g every 12 h + FOF 24 g CI + MEM EI 1 g every 8 h	8
PT8	P. aeruginosa	16	K. pneumoniae KPC		CZA EI 5 g every 12 h + FOF 24 g CI then FOF was stopped and FDC 2 g EI every 8 h was started	21
PT9	P. aeruginosa	16	K. pneumoniae		CZA EI 1.25 g every 8 h	3
PT10	P. fluorescens	2		MEM	CZA EI 1.25 g every 8 h + MER 1 g EI every 12 h	9
PT11	P. aeruginosa	16	K. pneumoniae ESBL	MEM + AMK inhaled	CZA EI 5 g every 12 h + FOF 24 g CI, then FOF was stopped and FDC 2 g EI every 8 h was started	5
PT12	S. maltophila	16		SXT + AMP	CZA EI 5 g every 12 h + SXT 15 mg/kg/day	11
PT13	P. aeruginosa	8		MEM	CZA II over 2 h of 2.5 g + FOF 24 g CI, then FOF was stopped, and FDC 2 g EI every 8 h was started	9
PT14	P. putida	8	S. maltophila	FEP	CZA EI 5 g every 12 h + FOF 24 g CI	10
PT15	P. aeruginosa	4	S. marcescens ESBL	MEM	CZA EI 5 g every 12 h + FOF 24 g cCI	9
PT16	P. aeruginosa	8	S. maltophila	MEM	CZA EI 5 g every 12 h + FOF 24 g CI	25
PT17	B. cepacia	16	E. cloacae ESBL	MEM	CZA EI 5 g every 12 h + SXT 15 mg/kg/day	9
PT18	P. aeruginosa	2	S. maltophila	MEM	CZA EI 5 g every 12 h	10
PT19	P. aeruginosa	2		TZP	CZA EI 5 g every 12 h + MER EI every 8 h	5
PT20	S. maltophila	16			CZA EI 5 g every 12 h + AZT 2 g every 8 h	7
PT21	P. aeruginosa	2		MEM	CZA EI 1.25 g every 8 h + AMK inhaled	12
PT22	P. aeruginosa	2	P. aeruginosa	CAZ then MEM	CZA EI 1.25 g every 8 h + MEM 1 g EI every 8 h	5
PT23	P. aeruginosa	2		CAZ then C/T	CZA EI 1.25 g every 8 h + MEM 1 g EI every 8 h	4

EI = extended infusion, II = intermittent infusion, CI = continuous infusion, FDC = cefiderocol, MEM = meropenem, FEP = cefepime, TZP = piperacillin/tazobactam, CAZ = ceftazidime, COL = colistin, AMP = ampicillin, STX = trimethoprim-sulfamethoxazole, CZA = ceftazidime/avibactam, FOF = fosfomycin, and AMK = amikacin.