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. 2022 Jul 22;23(15):8075. doi: 10.3390/ijms23158075

Figure 2.

Figure 2

Ex vivo analysis of the effect of GcMAF-RF on immunocompetent cells. (A) Allostimulatory activity of human DCs activated by either the standard activator LPS or various concentrations of GcMAF-RF. The allostimulatory activity of DCs in the absence of activators was taken to be unity (red line). * significant differences from DCs without activators, p < 0.05 (Mann–Whitney U test). (B) The effect of GcMAF-RF on M1 polarization of human macrophages. Polarization was assessed based on allostimulatory activity of M1 polarized macrophages. LPS and GcMAF (50 and 250 ng/mL) were used as maturation inducers. Allostimulatory activity of intact macrophages was taken to be unity (red line). * significant differences from unstimulated macrophages, p < 0.01 (Mann–Whitney U test). Impact—the ratio between stimulated DCs or macrophages and intact ones.