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. 2022 Jul 22;23(15):8075. doi: 10.3390/ijms23158075

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The additive effect of GcMAF on primary induction of the immune response by Karanahan therapy in mice with Lewis carcinoma on day 16. (A) CD11b + LyC + cells. (B) CD11b + LyG+ cells. (C) CD3 + CD4 + cells. (D) CD4 + CD25 + FOXP3+ cells. (E) CD3 + CD8 + cells. (F) CD3 + CD8 + Perf + killer T cells. (G) CD3 + CD8 + Perf + cells among CD3 + CD8 + cells. (H) CD3-NKp46 + CD11b + cells. (I) CD80 + CD83 + cells. The black asterisk shows a significant difference between the control and experimental groups. The hash stands for a significant difference between the experimental groups. The confidence level is p < 0.05 (Mann–Whitney U test, n = 3). (J) Cytolytic activity of PMs against Lewis carcinoma cells. Median (line) with interquartile range (box) are shown.