Table 1. Thermodynamic Parameters Obtained for the CDK6–Taurine Complex from ITC.
Ka (association constant) M–1 | ΔH (enthalpy change) cal/mol | ΔS (cal/mol/deg) |
---|---|---|
Ka1 = 1.93 × 104 ± 1.1 × 104 | ΔH1 = −1.895 × 104 ± 1.54 × 104 | ΔS1 = −43.9 |
Ka2 = 1.54 × 105 ± 4.1 × 104 | ΔH2 = 1.04 × 106 ± 3.18 × 105 | ΔS2 = 3.52 × 103 |
Ka3 = 2.29 × 105 ± 5.2 × 104 | ΔH3 = −2.88 × 106 ± 6.05 × 105 | ΔS3 = −9.64 × 103 |
Ka4 = 2.29 × 105 ± 5.2 × 104 | ΔH4 = 3.519 × 106 ± 5.45 × 105 | ΔS4 = 1.18 × 104 |