Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 26;10(8):1186. doi: 10.3390/vaccines10081186

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Significantly reduced levels of anti-SARS-CoV-2 inhibiting antibodies 6 months after two BNT162b2 vaccine doses in all recruited subjects. (A) Ability of serum from healthy controls (HCs, shown in purple), patients with IBD receiving non-anti-TNFα treatment (non-anti-TNFα, shown in blue) and patients with IBD receiving anti-TNFα treatment (anti-TNFα, shown in red) to inhibit SARS-CoV-2 RBD binding to ACE2 receptor. Values measured with ELISA and presented as % inhibition (y axis). Visit 3 (filled circles), visit 4 (open triangles)—after two vaccine doses, 1 and 6 months, respectively. Zero inhibition was set as the value of RBD without added sera. Statistical analysis was carried out using independent sample Kruskal–Wallis test, ****—p < 0.0001. (B) Correlation between anti-S titer and inhibition responses. (C) Correlation between neutralizing activity and inhibition responses. Abbreviations: RBD—receptor-binding domain; ACE2—angiotensin-converting enzyme-2.