Figure 4.

Cannabinoid type 1 (CB₁) receptor antagonist prevented 1400 W effects on restraint stress-induced behavioral consequences in the elevated plus-maze (EPM) 24 h later. Pretreatment with the CB₁ receptor antagonist AM251 (100 pmol) suppressed the 1400 W effect in the anxiety index (A) and percentage of entries (C) and time (D) in the open arms of the maze. There was no change in the enclosed arm entries (B). Bars represent the mean ± standard error of the mean (SEM). *Indicates p < 0.05 in the Student t-test; ^#Indicates p < 0.05 in Tukey post-hoc test. n = 11, 11, 9, 10, and 9 for Naïve-Veh+Veh, Stress-Veh+Veh, Stress-Am251+Veh, Stress-Veh+1400 W and Stress-AM251+1400 W, respectively.