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. 2022 Jul 28;12:12899. doi: 10.1038/s41598-022-17088-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EGCG inhibits entry mediated by spike of highly pathogenic CoVs and a pre-emergent bat CoV. (a-b) EGCG pre-treatment reduced entry of SARS-CoV-1, MERS-CoV, SARS-CoV-2 (ancestral, delta or omicron), or WIV1-CoV pseudoparticles into Huh7 or A549-ACE2 cells. Mean values with standard error of the mean from three independent experiments each done in triplicate are plotted. (c) EGCG inhibits VSV-SARS-CoV-2 infection in Huh7, A549-ACE2 B9 and Calu-3 cells. Its antiviral potency is dependent on the multiplicity of infection (MOI). Mean values with standard deviation of three independent experiments each in duplicate are plotted. (d) Representative images are shown. Scale bar: 200 μm.