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Targeting the MUC1-C extracellular domain. MUC1-C consists of a 58 aa extracellular domain (ED), 28 aa transmembrane domain (TM) and a 72 aa cytoplasmic domain (CD). The MUC1-C ED includes α3 and α4 helices that are exposed with MUC1-C activation and are targets for monoclonal antibodies (MAbs). MAb 3D1 has been generated against the α3 helix and is under development as CAR T cell and ADC approaches. Figure modified from [58,120].
