Table 1.

Duplex Sequencing mutation frequencies and lacZ assay mutant frequencies in the bone marrow of the same MutaMouse animals exposed to BaP

Assay	Dose (mg/kg/day)	Mean MFa (×  10− 7)	SD (×  10− 7)	Fold Changeb	Variance (× 10− 16)	p value
DS	0	1.3	0.25		6.1
	12.5	3.3	0.3	2.5	8.9	2.7 × 10−9
	25	6.8	0.64	5.2	41	6.7 × 10−14
	50	10.4	0.7	8.0	48	6.7 × 10−16
		(× 10−5)	(× 10−5)		(× 10−11)
lacZ	0	4.3	0.6		3.7
	12.5	109.4	24.3	25.3	5890	1.3 × 10−13
	25	313.6	57.4	72.3	32,900	< 1.0 × 10−16
	50	572.8	157.1	133	216,000	< 1.3 × 10− 16

^aDS MF shown as mutants per bp sequenced, lacZ mutant frequency shown as mutants per locus

^bFold change calculated relative to VC