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. 2022 Jul 25;11(8):1437. doi: 10.3390/antiox11081437

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic diagram of hyperoside (Hyp), which improves various liver diseases by reducing oxidative stress; CYP, cytochrome P450; Nrf2, nuclear factor erythroid 2-related factor 2; MAPK, mitogen-activated protein kinase; NFκB, nuclear factor kappa-light-chain-enhancer of activated B cells; HO-1, heme oxygenase-1; GCLC, glutamate–cystein ligase catalytic subunit; NQO1, NAD(P)H quinone dehydrogenase 1; TNF-α, tumor necrosis factor-alpha; IL-6, interleukin-6; ATF3, cyclic AMP-dependent transcription factor; HSC, hepatic stellate cell; and ECM, extracellular matrix.