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. 2022 Jul 28;19:193. doi: 10.1186/s12974-022-02544-5

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© The Author(s) 2022, corrected publication 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Glyphosate exposure alters the brain transcriptome. A Volcano plot showing the differential expression analysis results after dosage regression. Genes in blue and red were downregulated and upregulated, respectively, after glyphosate exposure (adj-p < 0.05). B Volcano plots showing differential expression in individual cell class following deconvolution analysis. A: astrocytes; EC: endothelial cells; GB_N: GABAergic neurons; GL_N: glutamatergic Neurons; M: microglia; NoEnrichment: unclassified cell type; O: oligodendrocytes; OPC: oligodendrocyte progenitor cells. Colored dots represent dysregulated gene expression. C Boxplot of normalized counts for Plp1 showing significant dose-dependent upregulation (p adj. = 0.034). D Boxplot of normalized counts for Cntn2 showing significant dose-dependent upregulation (p adj. = 0.029). E Boxplot of normalized counts for Arhgef10 showing significant dose-dependent upregulation (p adj. = 0.010). F Boxplot of normalized counts for Abca2 showing significant dose-dependent upregulation (p adj. = 0.008)