Figure 3.

Illustration of the construction of animal models and SF MN patch treatment. (A) Time nodes of different stages of the whole experimental process. (B) On day 28, four rabbit ear scar models were established successfully on the ventral side of each rabbit ear, as evidenced by the apparent excess and disordered collagen deposition in the pathological scar tissue compared to the normal tissue. Scale bars, 10 mm, 5 mm, and 200 μm. (C) On day 30, SF MN patches were employed to treat the hypertrophic scars. Successful penetration was verified by tissue sectioning and H&E staining. Scale bars, 10 mm, 5 mm, 1 mm, 500 μm, and 200 μm.