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. 2022 Jul 23;27(15):4723. doi: 10.3390/molecules27154723

Table 4.

Four-component synthesis and antibacterial evaluation of pyrazole-dimedone derivatives 21.

graphic file with name molecules-27-04723-i004.jpg
Compound R Yield 21 (%) SA EF BS
CPM (mm) MIC (μg/L) CPM (mm) MIC (μg/L) CPM (mm) MIC (μg/L)
21a 2,4-diClC6H3 78 13 32 14 32 12 32
21b C6H5 62 15 32 13 16 15 16
21c 4-ClC6H4 50 13 32 24 32 16 32
21d 4-MeC6H4 62 16 32 16 32 18 32
21e 3-MeC6H4 66 19 16 15 32 14 64
21f 4-BrC6H4 71 14 32 13 64 15 32
21g 3-BrC6H4 70 14 32 15 32 16 32
21h 4-NO2C6H4 52 12 64 14 32 16 32
21i 3-NO2C6H4 63 14 32 12 64 17 32
21j 4-MeOC6H4 64 10 64 13 32 10 32
21k 4-FC6H4 57 13 32 13 32 20 8
21l 4-CF3C6H4 76 16 16 16 32 16 32
21m 2,6-diClC6H3 40 15 32 13 32 12 32
21n 2-Naphthyl 76 14 32 13 32 15 32
21o 2-Thienyl 75 13 32 20 32 15 16
Ciprofloxacin a -- -- 27 ≤0.25 24 ≤0.25 25 ≤0.25

a Positive control for the study. SA (Staphylococcus aureus), EF (Enterococcus faecalis), BS (Bacillus subtilis).