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. 2022 Jul 23;27(15):4723. doi: 10.3390/molecules27154723

Table 32.

Evaluation of spiroindenopyridazine-4H-pyrans 45 against the cancer cell lines A549, PC-3, MCF-7, A375, LNCaP, and Normal cell HDF a.

graphic file with name molecules-27-04723-i046.jpg
Compound Cyclic CH-Acid 44
in Table 10 		IC50 (μM)
A549 PC-3 MCF-7 A375 LNCaP HDF
45a graphic file with name molecules-27-04723-i047.jpg 40 >100 >100 70.7 32.1 >100
45b graphic file with name molecules-27-04723-i048.jpg >100 >100 >100 >100 >100 >100
45c graphic file with name molecules-27-04723-i049.jpg >100 >100 >100 >100 >100 >100
45d graphic file with name molecules-27-04723-i050.jpg >100 >100 >100 >100 >100 >100
45e graphic file with name molecules-27-04723-i051.jpg >100 >100 >100 >100 >100 >100
45f graphic file with name molecules-27-04723-i052.jpg >100 >100 >100 >100 >100 >100
45g graphic file with name molecules-27-04723-i053.jpg >100 >100 >100 >100 >100 >100
45h graphic file with name molecules-27-04723-i054.jpg >100 >100 >100 >100 >100 >100
45i graphic file with name molecules-27-04723-i055.jpg >100 >100 >100 >100 >100 >100
45j graphic file with name molecules-27-04723-i056.jpg >100 >100 >100 >100 >100 >100
Etoposide b -- 60 40 30 25.3 90 >100

a Reaction conditions: Cyanoacetohydrazide 42 (1 mmol), ninhydrin 43 (1 mmol), malononitrile 2 (1 mmol), cyclic CH-acid 44 (1 mmol), EtOH (10 mL), reflux, 6–12 h. b Standard drug for the study.