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Anticancer activity of compounds 128 and 129 against PC-3, SKOV3, and HeLa cell lines.
| |||||||
|---|---|---|---|---|---|---|---|
| Compound | R | R1 | X | Yield 128/129 (%) | IC50 (µg/mL) | ||
| PC-3 | SKOV3 | HeLa | |||||
| 128a | H | Me | -- | 92 | 9.7 | 35.6 | 25.9 |
| 128b | H | C6H5 | -- | 93 | 34.2 | 55.4 | 32.5 |
| 128c | Me | C6H5 | -- | 91 | 13.2 | 16.5 | 8.4 |
| 128d | C6H5 | C6H5 | -- | 93 | 190.3 | 234.3 | 91.3 |
| 129a | -- | -- | O | 89 | 8.9 | 4.7 | 11.3 |
| 129b | -- | -- | S | 90 | 73.4 | 9.3 | 14.3 |
| 129c | -- | Me | -- | 91 | 42.1 | 35.5 | 32.8 |
| 129d | -- | C6H5 | -- | 90 | 18.9 | 5.4 | 15.9 |
| Doxorubicin a | -- | -- | -- | -- | 2.1 | 2.3 | 1.9 |
a Standard drug for the study.
